SEC inhibitor KL-1 (Synonyms: KL-1) |
| رقم الكتالوجGC38063 |
مثبط SEC KL-1 (KL-1) ، مركب الرصاص المحاكي للببتيد ، هو مثبط قوي وانتقائي للاستطالة الفائقة (SEC) ويعطل التفاعل بين بروتين السقالات SEC AFF4 و P-TEFb ، مما يؤدي إلى ضعف إطلاق Pol II من مواقع التوقف القريبة للمروج وانخفاض متوسط معدل استطالة النسخيُظهر مثبط SEC KL-1 تأثيرًا مثبطًا يعتمد على الجرعة على تفاعل AFF4-CCNT1 مع Ki البالغ 3.48 ميكرومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 900308-84-1
Sample solution is provided at 25 µL, 10mM.
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SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].
[1]. Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.
| Cas No. | 900308-84-1 | SDF | |
| المرادفات | KL-1 | ||
| Canonical SMILES | O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=CC(OC)=C2)=O | ||
| Formula | C18H16ClNO4 | M.Wt | 345.78 |
| الذوبان | DMSO: 41.67 mg/mL (120.51 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.892 mL | 14.4601 mL | 28.9201 mL |
| 5 mM | 578.4 μL | 2.892 mL | 5.784 mL |
| 10 mM | 289.2 μL | 1.446 mL | 2.892 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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