SEC inhibitor KL-1 (Synonyms: KL-1) |
| رقم الكتالوجGC38063 |
مثبط SEC KL-1 (KL-1) ، مركب الرصاص المحاكي للببتيد ، هو مثبط قوي وانتقائي للاستطالة الفائقة (SEC) ويعطل التفاعل بين بروتين السقالات SEC AFF4 و P-TEFb ، مما يؤدي إلى ضعف إطلاق Pol II من مواقع التوقف القريبة للمروج وانخفاض متوسط معدل استطالة النسخيُظهر مثبط SEC KL-1 تأثيرًا مثبطًا يعتمد على الجرعة على تفاعل AFF4-CCNT1 مع Ki البالغ 3.48 ميكرومتر
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Cas No.: 900308-84-1
Sample solution is provided at 25 µL, 10mM.
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SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].
[1]. Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.
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