Lavendustin B |
رقم الكتالوجGC45494
One-Click Copy Product Info
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Lavendustin B هو مثبط لتفاعل HIV-1 Integrase مع LEDGF / p75 مع IC50 من 94.07 ميكرومترLavendustin B هو مثبط GLUT1 تنافسي لـ ATP مع Ki من 15 ميكرومتريعتبر Lavendustin B أيضًا مثبطًا ضعيفًا لكينازات التيروزين
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 125697-91-8
Sample solution is provided at 25 µL, 10mM.
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Lavendustin B is a competitive inhibitor of glucose transporter 1 (Glut1; Ki = 15 μM).1 It is also an inhibitor of the interaction between HIV-1 integrase and LEDGF/p75 (IC50 = 94.07 μM).2 Lavendustin B is a weak inhibitor of tyrosine kinases (IC50 = 0.49 μg/ml) and has been used as a negative control for the protein tyrosine kinase inhibitor lavendustin A .3,4,5
References
1. Vera, J.C., Reyes, A.M., VelÁsquez, F.V., et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry 40(3), 777-790 (2001).
2. De Luca, L., Morreale, F., Christ, F., et al. New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: Virtual screening and activity assays. Eur. J. Med. Chem. 68, 405-411 (2013).
3. Onoda, T., Iinuma, H., Sasaki, Y., et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J. Nat. Prod. 52(6), 1252-1257 (1989).
4. Hu, D.E., and Fan, T.-P.D. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br. J. Pharmacol. 114(2), 262-268 (1995).
5. Alioua, A., Mahajan, A., Nishimaru, K., et al. Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction. Proc. Natl. Acad. Sci. USA 99(22), 14560-14565 (2002).
| Cas No. | 125697-91-8 | SDF | |
| Canonical SMILES | OC1=CC=CC=C1CN(C2=CC(C(O)=O)=C(O)C=C2)CC3=CC=CC=C3O | ||
| Formula | C21H19NO5 | M.Wt | 365.4 |
| الذوبان | DMF: 10 mg/mL,DMSO: 10 mg/mL,Ethanol: 10 mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7367 mL | 13.6836 mL | 27.3673 mL |
| 5 mM | 547.3 μL | 2.7367 mL | 5.4735 mL |
| 10 mM | 273.7 μL | 1.3684 mL | 2.7367 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)