Semax (Synonyms: ACTH4-7-PGP) |
| رقم الكتالوجGC45565 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 80714-61-0
Sample solution is provided at 25 µL, 10mM.
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Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) (4-10) that has neuroprotective, analgesic, and anxiolytic properties.1,2,3 In vivo, semax (0.3 mg/kg) reduces cortical nitric oxide (NO) production and the number of neurological disturbances, such as seizures, falling, and twisting, in a rat model of global ischemia.1 It decreases acetic acid-induced writhing and nociception in a hind paw compression test in mice when administered at doses ranging from 0.015 to 0.5 mg/kg.2 Semax also increases time spent in the open arms in the elevated plus maze, indicating anxiolytic activity, in a rat model of maternal deprivation-induced anxiety.3
References
1. Bashkatova, V.G., Koshelev, V.B., Fadyukova, O.E., et al. Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia. Brain Res. 894(1), 145-149 (2001).
2. Ivanova, D.M., Levitskaya, N.G., Andreeva, L.A., et al. Comparative study of analgesic potency of ACTH4-10 fragment and its analog semax. Bull. Exp. Biol. Med. 143(1), 5-8 (2007).
3. Volodina, M.A., Sebentsova, E.A., Glazova, N.Y., et al. Semax attenuates the influence of neonatal maternal deprivation on the behavior of adolescent white rats. Bull. Exp. Biol. Med. 152(5), 560-563 (2012).
| Cas No. | 80714-61-0 | SDF | |
| المرادفات | ACTH4-7-PGP | ||
| Canonical SMILES | OC([C@H]1N(C(CNC([C@H]2N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCSC)=O)CCC(O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)CCC2)=O)=O)CCC1)=O | ||
| Formula | C37H51N9O10S | M.Wt | 813.9 |
| الذوبان | DMF: 1mg/mL,DMSO: 5mg/mL,PBS (pH 7.2): 10mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.2287 mL | 6.1433 mL | 12.2865 mL |
| 5 mM | 0.2457 mL | 1.2287 mL | 2.4573 mL |
| 10 mM | 0.1229 mL | 0.6143 mL | 1.2287 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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