11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester (Synonyms: 11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester) |
رقم الكتالوجGF44560
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11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester is a eudesmane-type (germacranolide-derived) sesquiterpene lactone glucopyranosyl ester isolated from Taraxacum officinale, and 11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester exhibits relatively low cytotoxicity toward cells.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 75911-16-9
Sample solution is provided at 25 µL, 10mM.
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11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester is a eudesmane-type (germacranolide-derived) sesquiterpene lactone glucopyranosyl ester isolated from Taraxacum officinale, and 11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester exhibits relatively low cytotoxicity toward cells. 11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester can be used for natural product isolation and identification, phytochemical profiling, structure–activity relationship (SAR) control studies of sesquiterpene lactones, and method validation for the analysis of sesquiterpene lactone constituents in food and herbal matrices[1-4].
In vitro, 11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester (0.91mM) was used to treat Hep G2.2.15 cells (a human hepatoblastoma cell line stably transfected with the hepatitis B virus (HBV) genome) for 12 days. 11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester suppressed the secretion of HBV surface antigen (HBsAg) and concurrently inhibited the secretion of HBV e antigen (HBeAg)[5].
References:
[1] Martinez M, Poirrier P, Chamy R, et al. Taraxacum officinale and related species-An ethnopharmacological review and its potential as a commercial medicinal plant. J Ethnopharmacol. 2015 Jul 1;169:244-62.
[2] Fan M, Zhang X, Song H, et al. Dandelion (Taraxacum Genus): A Review of Chemical Constituents and Pharmacological Effects. Molecules. 2023 Jun 27;28(13):5022.
[3] Laila U, Kaur J, Sharma K, et al. Dandelion (Taraxacum officinale): A Promising Source of Nutritional and Therapeutic Compounds. Recent Adv Food Nutr Agric. 2025;16(1):41-56.
[4] Jeon HJ, Kang HJ, Jung HJ, et al. Anti-inflammatory activity of Taraxacum officinale. J Ethnopharmacol. 2008 Jan 4;115(1):82-8.
[5] Liu J, Zhang N, Liu M. A new inositol triester from Taraxacum mongolicum. Nat Prod Res. 2014;28(7):420-3.
| Cell experiment [1]: | |
Cell lines | Hepatitis B virus transfected Hep G2.2.15 cell line (human hepatoblastoma-derived cell line stably harboring HBV genome) |
Preparation Method | Hep G2.2.15 cells were cultured in RPMI-1640 medium supplemented with 1% antibiotics (streptomycin and penicillin) and 10% fetal bovine serum, and maintained in an incubator at 37°C, 5% CO₂. Hep G2.2.15 cells were treated with the 11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester at 0.91mM for 12 days. |
Reaction Conditions | 0.91mM; 12 days |
Applications | 11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester inhibited the secretion of HBV surface antigen (HBsAg) and also suppressed the secretion of HBV e antigen (HBeAg). |
References: | |
| Cas No. | 75911-16-9 | SDF | |
| المرادفات | 11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester | ||
| Formula | C21H30O9 | M.Wt | 426.46 |
| الذوبان | Storage | Store at -20°C,protect from light | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3449 mL | 11.7244 mL | 23.4489 mL |
| 5 mM | 469 μL | 2.3449 mL | 4.6898 mL |
| 10 mM | 234.5 μL | 1.1724 mL | 2.3449 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)