Grepafloxacin hydrochloride (Synonyms: OPC-17116 hydrochloride; dl-Grepafloxacin hydrochloride) |
| رقم الكتالوجGC65875 |
Grepafloxacin (OPC-17116) هيدروكلوريد هو مضاد حيوي فعال عن طريق الفم من الفلوروكينولون مع نشاط قوي ضد مسببات الأمراض التنفسية المكتسبة من المجتمع بما في ذلك الالتهاب الرئوي العقدية. يحتوي هيدروكلوريد Grepafloxacin على اختراق عالي للأنسجة ومظهر ديناميكي دوائي واعد.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 161967-81-3
Sample solution is provided at 25 µL, 10mM.
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Grepafloxacin (OPC-17116) hydrochloride is an oral actively fluoroquinolone antibiotic with potent activity against community-acquired respiratory pathogens including Streptococcus pneumonia. Grepafloxacin hydrochloride has high tissue penetration and a promising pharmacodynamic profile[1][2][3][4].
Grepafloxacin (OPC-17116; 0-1 mg/L; 14-21 d) hydrochloride has antibiotic activity with a MIC value of ≤ 0.006 mg/L for E. coli strain[1].
Grepafloxacin (0-1 mg/L; 3 h) hydrochloride has antimicrobial activity against mycobacteria in macrophages with a MIC value of 0.5 mg/L for M. avium[1].
Grepafloxacin hydrochloride exhibits potent in vitro antibacterial activity against Gram-positive bacteria such as Streptococcus pneumoniae and high in vivo efficacy on the experimental systemic infections caused by the Gram-positive and -negative bacteria tested[4].
Grepafloxacin (OPC-17116; 200 mg/kg; p.o.; Balb/c mice) hydrochloride displays good safety profile in terms of phototoxicity[2].
Grepafloxacin (25-200 mg/kg; p.o.; 5 days/week for 4 weeks; female C57BL6/J-Lyst bg-J/ mice/beige mice) hydrochloride has modest activities in both intranasal (IN) infection and intravenous (IV) Mycobacterium avium infection models[3].
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