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GRP-60367 hydrochloride

رقم الكتالوجGC60885

هيدروكلوريد GRP-60367 هو أول مثبط لدخول فيروس داء الكلب (RABV) من الدرجة الأولى في فئته مع فعالية نانومولار ضد بعض سلالات RABV

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GRP-60367 hydrochloride التركيب الكيميائي

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
102٫00
متوفر
5mg
93٫00
متوفر
10mg
139٫00
متوفر

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مراجعات العميل

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein[1].

GRP-60367 (0.1 nM-1000 μM) confirms specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC50s ranging from 2 to 52 nM on different host cell lines[1]. Cell Viability Assay[1] Cell Line: BEAS-2B, 293T, or Hep-2 cell lines

[1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.

مراجعات

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