Histone H3K27Me3 (21-44)-K-biotin (trifluoroacetate salt) (Synonyms: ATKAAR-K(Me3)-SAPATGGVKKPHRYRPG-K(Biotin), H3(21-44)K27me3 Substrate, Histone H3 (21-44) (Lys27me3), Lys(Me3)27-Histone H3 (21-44)-K(Biotin)) |
| رقم الكتالوجGC43850 |
Histone H3K27Me3 (21-44)-K-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and H3.2 sequences.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Histone H3K27Me3 (21-44)-K-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and H3.2 sequences. It is trimethylated at lysine 27 and biotinylated via a C-terminal lysine linker. Trimethylation of histone H3 at lysine 27 is associated with gene silencing. It is involved in tumor progression through its regulation by enhancer of zeste homolog 2 (EZH2) and transcriptional repression of tumor suppressor genes. Levels of H3K27Me3 are reduced in 293 T-REx cells containing EEDR236T and SUZ12G610V mutations and in lymphoblastoid cells isolated from patients with Weaver syndrome, a rare overgrowth disorder characterized by EZH2, EED, or SUZ12 mutations, cancer susceptibility, and various distinctive physical features.
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