Homocarnosine (Synonyms: γ-Aminobutyrylhistidine, γ-Aminobutyryl-L-histidine, NSC 92522) |
رقم الكتالوجGC48897
One-Click Copy Product Info
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Homocarnosine هو ثنائي ببتيد حمض γ-aminobutyric (GABA) والهيستيدين الفريد للدماغ
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3650-73-5
Sample solution is provided at 25 µL, 10mM.
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Homocarnosine is a dipeptide composed of GABA and L-histidine that has been found in cerebrospinal fluid and the brain.1 It inhibits lipid peroxidation induced by AAPH when used at a concentration of 10 mM.2 Homocarnosine (1 mM) decreases lactate dehydrogenase (LDH) and prostaglandin E2 release from PC12 cells in an in vitro model of ischemia induced by oxygen-glucose deprivation.3 It reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).4 Homocarnosine (5 mg/animal) reduces mortality in a mouse model of subcutaneous S. aureus infection.5
1.Crush, K.G.Carnosine and related substances in animal tissuesComp. Biochem. Physiol.34(1)3-30(1970) 2.Kohen, R., Yamamoto, Y., Cundy, K.C., et al.Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brainProc. Natl. Acad. Sci. USA85(9)3175-3179(1988) 3.Tabakman, R., Lazarovici, P., and Kohen, R.Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemiaJ. Neurosci. Res.68(4)463-469(2002) 4.Huang, J., Wang, T., Yu, D., et al.L-Homocarnosine attenuates inflammation in cerebral ischemia-reperfusion injury through inhibition of nod-like receptor protein 3 inflammasomeInt. J. Biol. Macromol.118(Pt A)357-364(2018) 5.Mukkada, A.J., Nutini, L.G., and Cook, E.S.Prophylactic effects of γ-aminobutyrylhistidine (homocarnosine) on experimental staphylococcal infections in miceAppl. Microbiol.18(4)641-645(1969)
| Cas No. | 3650-73-5 | SDF | |
| المرادفات | γ-Aminobutyrylhistidine, γ-Aminobutyryl-L-histidine, NSC 92522 | ||
| Canonical SMILES | OC([C@H](CC1=CN=CN1)NC(CCCN)=O)=O | ||
| Formula | C10H16N4O3 | M.Wt | 240.3 |
| الذوبان | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.1615 mL | 20.8073 mL | 41.6146 mL |
| 5 mM | 832.3 μL | 4.1615 mL | 8.3229 mL |
| 10 mM | 416.1 μL | 2.0807 mL | 4.1615 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)