Hygrolidin (Synonyms: Antibiotic 1166C) |
| رقم الكتالوجGC43882 |
Hygrolidin هو مضاد حيوي من 16 ماكرولايد ينتج عن Streptomyces hygroscopicus D-1166
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Cas No.: 83329-73-1
Sample solution is provided at 25 µL, 10mM.
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Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively).
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