IPN-60090 dihydrochloride |
| رقم الكتالوجGC60937 |
IPN-60090 ثنائي هيدروكلوريد هو مثبط فعال عن طريق الفم وانتقائي للغاية من الجلوتاميناز 1 (GLS1 ؛ IC50 \u003d 31 نانومتر) ، مع عدم وجود نشاط ملحوظ ضد GLS-2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2102101-72-2
Sample solution is provided at 25 µL, 10mM.
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IPN-60090 dihydrochloride is an orally bioavailable and selective inhibitor of GLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 dihydrochloride can be used in the research of GLS1-mediated diseases[1][2].
IPN-60090 dihydrochloride (Example 1) has an IC50 against GLS1 and an EC50 against A549 cell proliferation of <100 nM[2].
[1]. Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2. [2]. Philip Jones, et al. Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide. US20170174661A1.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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