K-Ras ligand-Linker Conjugate 6 |
| رقم الكتالوجGC39714 |
يشتمل K-Ras ligand-Linker Conjugate 6 على ligand لشريحة تجنيد K-Ras ، ورابط PROTAC ، الذي يقوم بتجنيد ligases E3 (مثل VHL و CRBN و MDM2 و IAP)يمكن استخدام K-Ras ligand-Linker Conjugate 6 في تخليق PROTAC K-Ras Degrader-1 ، وهو مزيل مواد PROTAC K-Ras القوي الذي يظهر فعالية تحلل ≥70٪ في خلايا SW1573
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Cas No.: 2378261-89-1
Sample solution is provided at 25 µL, 10mM.
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K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
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