K41498 TFA |
| رقم الكتالوجGC64678 |
K41498 TFA هو مضاد لمستقبل CRF2 قوي وانتقائي للغاية مع قيم Ki تبلغ 0.66 نانومتر و 0.62 نانومتر و 425 نانومتر لمستقبلات CRF2α و CRF2β و CRF1 البشرية على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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K41498 TFA is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively. K41498 TFA is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K41498 TFA can be used for hypotension study[1].
[1]. A RÜhmann, et al. Design, synthesis and pharmacological characterization of new highly selective CRF(2) antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides. 2002 Mar;23(3):453-60.
[2]. A J Lawrence, et al. The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain. Br J Pharmacol
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