Latanoprostene Bunod (Synonyms: BOL-303259-X, NCX 116, PF-3187207) |
| رقم الكتالوجGC44039 |
Latanoprostene bunod (LBN) ، وهو نظير لأكسيد النيتريك (NO) يتبرع بالبروستاغلاندين F2a ، هو علاج موضعي للعيون لتقليل ضغط العين (IOP) في المرضى الذين يعانون من الجلوكوما مفتوح الزاوية أو ارتفاع ضغط الدم في العين (OHT)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 860005-21-6
Sample solution is provided at 25 µL, 10mM.
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Latanoproste bunod is a nitric oxide-donating prostaglandin F2α (FP) receptor agonist that is converted to latanoprost (free acid) and nitric oxide (NO) in vivo. It induces cGMP accumulation in PC12 and HEK293 cells (EC50s = 1.6 and 9.2 μM, respectively). Topical administration of latanoprost bunod (0.036% solution) reduces intraocular pressure (IOP) in canine and rabbit models of glaucoma. It also decreases IOP in a cynomolgus monkey model of laser-induced ocular hypertension.
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