LC3-mHTT-IN-AN2 |
| رقم الكتالوجGC39313 |
LC3-mHTT-IN-AN2 (المركب AN2) هو مركب رابط mHTT-LC3 ، والذي يتفاعل مع كل من بروتين هنتنغتين الطافر (mHTT) و LC3B ولكن ليس مع wtHTT أو بروتينات تحكم غير ذات صلة
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Cas No.: 7758-73-8
Sample solution is provided at 25 µL, 10mM.
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LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
[1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.
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