Leukotriene F4 (Synonyms: LTF4) |
رقم الكتالوجGC18845
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Leukotriene F4 (LTF4) ، هو دهون ينتمي إلى عائلة Cysteinyl Leukotriene (CysTL)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 83851-42-7
Sample solution is provided at 25 µL, 10mM.
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LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. [1] The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4. [1] [2]
Reference:
[1]. Bernstrom, K., and Hammarström, S. A novel leukotriene formed by transpeptidation of leukotriene E4. Biochemical and Biophysical Research Communications 109, 800-804 (1982).
[2]. Lord, A., Charleson, S., and Letts, L.G. Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs in vitro. Prostaglandins 29, 651-660 (1985).
| Cas No. | 83851-42-7 | SDF | |
| المرادفات | LTF4 | ||
| Chemical Name | 5S-hydroxy-6R-(S-γ-glutamylcysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid | ||
| Canonical SMILES | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](NC(CC[C@H](N)C(O)=O)=O)C(O)=O)[C@@H](O)CCCC(O)=O | ||
| Formula | C28H44N2O8S | M.Wt | 568.7 |
| الذوبان | >50 mg/ml (per Ramki Iyer) in DMSO, >50 mg/ml (per Ramki Iyer) in DMF, >50 mg/ml (per Ramki Iyer) in Ethanol | Storage | Store at -80°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.7584 mL | 8.792 mL | 17.584 mL |
| 5 mM | 351.7 μL | 1.7584 mL | 3.5168 mL |
| 10 mM | 175.8 μL | 879.2 μL | 1.7584 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >97.00% Appearance: A solution in methanol
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)