LNT 1 |
| رقم الكتالوجGC50481 |
LNT 1 (المركب 1) هو مثبط نوكلياز داخلي 1 (FEN1). يرتبط LNT 1 بالموقع النشط لـ FEN1 ويحقق جزئيًا تثبيطًا عن طريق تنسيق أيونات Mg2+.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 824983-91-7
Sample solution is provided at 25 µL, 10mM.
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Potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.
Exell et al (2016) Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 12 815 PMID:27526030 |Ward et al (2017) Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 12 e0179278 PMID:28628639
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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