LRE1 |
| رقم الكتالوجGC33296 |
LRE1 هو مثبط محدد ومثبط خيفي لانزيم محلقة adenylyl القابل للذوبان
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Cas No.: 1252362-53-0
Sample solution is provided at 25 µL, 10mM.
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LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.
LRE1 binds to the bicarbonate activator binding site and inhibits soluble adenylyl cyclase (sAC) via a unique allosteric mechanism[1]. LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition[1].LRE1 (0.5-100 μM, 60 minutes ) inhibits sperm and mitochondrial functions of sAC[1].|| Western Blot Analysis[1]||Cell Line:|Mouse cauda sperm|Concentration:|0.5-100 µM|Incubation Time:|60 minutes |Result:|LRE1 inhibits sAC dependent sperm capacitation[1].
[1]. Ramos-Espiritu L, et al. Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat Chem Biol. 2016 Oct;12(10):838-44.
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