LY518674 |
| رقم الكتالوجGC39399 |
LY518674 هو مضاد قوي وانتقائي لـ PPARα ، مع EC50 يبلغ 42 نانومتر لـ PPARα البشري
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 425671-29-0
Sample solution is provided at 25 µL, 10mM.
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LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis[1][2][3].
[1]. Bravo Y, et al. Identification of the first potent, selective and bioavailable PPARα antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. [2]. Nissen SE, et al. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. JAMA. 2007 Mar 28;297(12):1362-73. [3]. Khera AV, et al. Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. Eur Heart J. 2015 Nov 14;36(43):3020-2.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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