الصفحة الرئيسية>>Signaling Pathways>> Others>>Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP (Synonyms: Maleimidocaproyl-LValine-LCitrullinep-Aminobenzyl Alcohol pNitrophenyl Carbonate)

رقم الكتالوجGC17032

إن Mc-Val-Cit-PABC-PNP عبارة عن رابط ADC قابل للانقسام من نوع cathepsinيمكن استخدام Mc-Val-Cit-PABC-PNP في تخليق اتحادات الأدوية والأجسام المضادة (ADCs)

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Mc-Val-Cit-PABC-PNP التركيب الكيميائي

Cas No.: 159857-81-5

الحجم السعر المخزون الكميّة
50mg
19٫00
متوفر
100mg
30٫00
متوفر
250mg
60٫00
متوفر
500mg
84٫00
متوفر
1g
116٫00
متوفر

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مراجعات العميل

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  • GlpBio Citations

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Sample solution is provided at 25 µL, 10mM.

Description of Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

References:
[1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders

Chemical Properties of Mc-Val-Cit-PABC-PNP

Cas No. 159857-81-5 SDF
المرادفات Maleimidocaproyl-LValine-LCitrullinep-Aminobenzyl Alcohol pNitrophenyl Carbonate
Chemical Name (Z)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S,Z)-1-hydroxy-1-(((S)-5-((hydroxy(imino)methyl)amino)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopentan-2-yl)imino)-3-methylbutan-2-yl)hexanimidic acid
Canonical SMILES CC([C@@](/N=C(O)/CCCCCN1C(C=CC1=O)=O)([H])/C(O)=N/[C@@](C(NC2=CC=C(COC(OC3=CC=C(N(=O)=O)C=C3)=O)C=C2)=O)([H])CCCNC(O)=N)C
Formula C35H43N7O11 M.Wt 737.76
الذوبان ≥ 36.9mg/mL in DMSO Storage 4°C, protect from light, stored under nitrogen
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Mc-Val-Cit-PABC-PNP

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.3555 mL 6.7773 mL 13.5545 mL
5 mM 0.2711 mL 1.3555 mL 2.7109 mL
10 mM 0.1355 mL 0.6777 mL 1.3555 mL
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In vivo Formulation Calculator (Clear solution) of Mc-Val-Cit-PABC-PNP

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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