Meprednisone (Synonyms: Methylprednisone, NSC 527579, SCH 4358) |
| رقم الكتالوجGC15668 |
ميبريدنيزون هو جلايكورتيكويد ومشتق ميثلي من بريدنيزون
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1247-42-3
Sample solution is provided at 25 µL, 10mM.
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Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1].
References:
[1]. Scheuer, E. and E. Warshaw, Allergy to corticosteroids: update and review of epidemiology, clinical characteristics, and structural cross-reactivity. Am J Contact Dermat, 2003. 14(4): p. 179-87.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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