[Met5]-Enkephalin, amide (5-Methionine-enkephalin amide) |
| رقم الكتالوجGC31138 |
[Met5] - إنكيفالين ، أميد (5-ميثيونين-إنكيفالين أميد) هو ناهض لـ δ ؛ مستقبلات الأفيون وكذلك &zeta المفترضة ؛ (زيتا) مستقبلات الأفيون.
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![[Met5]-Enkephalin, amide (5-Methionine-enkephalin amide) التركيب الكيميائي](/media/struct/GC3/GC31138.png "[Met5]-Enkephalin, amide (5-Methionine-enkephalin amide) التركيب الكيميائي")
Cas No.: 60117-17-1
Sample solution is provided at 25 µL, 10mM.
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[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.
[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].
[1]. Stiene-Martin A, et al. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48. [2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8.
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