MGAT2-IN-1 (Synonyms: MGAT2-IN-1) |
| رقم الكتالوجGC31362 |
MGAT2-IN-1 هو مثبط نشط عن طريق الفم لـ monoacylglycerol acyltransferase (MGAT2) مع IC50 من 7.8 و 2.4 نانومتر للإنسان والفأر MGAT2 ، على التوالي
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Cas No.: 1800025-30-2
Sample solution is provided at 25 µL, 10mM.
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MGAT2-IN-1 is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.
MGAT2-IN-1 (3, 10 mg/kg, p.o.) dose-dependently suppresses plasma TG elevation, and plasma CM/TG AUC in mice. MGAT2-IN-1 does not decrease MG absorption but inhibits MGAT2-dependent TG/DG resynthesis. In the lipid utilization analysis, MGAT2-IN-1 significantly increases free fatty acid (FFA) and acylcarnitine levels. MGAT2-IN-1 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. MGAT2-IN-1 shows anti-diabetic effects in mice[1].
[1]. Take K, et al. Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization. PLoS One. 2016 Mar 3;11(3):e0150976.
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