MRS 1477 |
رقم الكتالوجGC50130 |
TRPV1 positive allosteric modulator
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 212200-21-0
Sample solution is provided at 25 µL, 10mM.
TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin in rats. Also prolongs capsaicin-induced hypothermia in mice.
Kaszas et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J.Pharmacol.Exp.Ther. 340 152 PMID:22005042 |Lebovitz et al (2012) Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Mol.Pain 8 PMID:22998799 |Roh et al (2008) Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorg.Med.Chem. 16 9349 PMID:18809334
Average Rating: 5
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