ω-Conotoxin MVIIC (trifluoroacetate salt) (Synonyms: SNX-230) |
| رقم الكتالوجGC45242 |
ω-Conotoxin MVIIC is a peptide originally isolated from the marine mollusk C.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ω-Conotoxin MVIIC is a peptide originally isolated from the marine mollusk C. magus. It blocks N-type calcium channels on rat superior cervical ganglions (SCGs) and P-type calcium channels on rat Purkinje neurons (Kds = 30 and ~50 nM, respectively, in the presence of 5 mM barium). It also blocks Q-type channels in rat CA3 neurons. ω-Conotoxin MVIIC binds to rat brain membranes (IC50 = 0.3 nM) and completely blocks calcium uptake by rat brain synaptosomes when used at a concentration of 2.5 μM in the presence of 5 mM potassium. It blocks potassium-evoked dopamine release from rat striatal slices (IC50 = ~128 nM) and potassium-evoked calcium-dependent glutamate release from rat brain synaptosomes.
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