Ontorpacept (Synonyms: TTI-621) |
رقم الكتالوجGC74589
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Ontorpacept (TTI-621) هو بروتين الاندماج الذائب الذي يتكون من SIRPα N-terminal (1-118) البشري المرتبط بمنطقة Fc من IgG1 البشري.
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Cas No.: 2131089-46-6
Sample solution is provided at 25 µL, 10mM.
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Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity.
Ontorpacept (0.001-1000 nmol/L; 2 h) dose-dependently increases macrophage phagocytosis of tumor cells with an average EC50 of 10 nmol/L in primary samples from patients with AML, MDS, multiple myeloma, B-ALL, and T-ALL[1].
Ontorpacept (8 mg/kg; i.p., 3 times a week for 4 weeks) shows antitumor effects in NOD. SCID mice with AML xenografts[1].
References:
[1]. Petrova PS, et al. TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding. Clin Cancer Res. 2017 Feb 15;23(4):1068-1079.
| Cas No. | 2131089-46-6 | SDF | |
| المرادفات | TTI-621 | ||
| Formula | M.Wt | ||
| الذوبان | Storage | ||
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.00% Appearance: A liquid
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)