Oritavancin (phosphate) (Synonyms: LY 333328) |
| رقم الكتالوجGC44515 |
Oritavancin (فوسفات) (LY333328 ثنائي الفوسفات) هو مضاد حيوي ببتيد سكري نشط عن طريق الفم مع نشاط ضد الكائنات إيجابية الجرام.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 192564-14-0
Sample solution is provided at 25 µL, 10mM.
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Oritavancin is a semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria. It inhibits transglycosylation and transpeptidation in the bacterial cell wall to disrupt membrane integrity. Oritavancin inhibits the growth of clinical isolates from skin and soft-tissue infections, including methicillin-resistant and -susceptible S. aureus (MRSA, MSSA), vancomycin-resistant and -susceptible E. faecium (VREF, VSRF), as well as other staphylococci, streptococci, and enterococci (MIC90s = ≤0.008-0.5 mg/L). Oritavancin inhibits growth of S. aureus in a neutropenic-mouse thigh model of infection (ED50 = 0.95 mg/kg for a single dose). It improves survival in a mouse inhalation model of B. anthracis Ames anthrax when administered prophylactically pre- and postexposure and when administered post symptom development. Formulations containing oritavancin have been used to treat bacterial skin infections.
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