الصفحة الرئيسية>>Natural Products>>Ouabain-d3

Ouabain-d3 (Synonyms: g-Strophanthin-d3)

رقم الكتالوجGC91439 Copy One-Click Copy Product Info

يهدف Ouabain-d3 إلى الاستخدام كمعيار داخلي لتحديد كمية الأواباين باستخدام تقنية GC- أو LC-MS.

Products are for research use only. Not for human use. We do not sell to patients.

Ouabain-d3 التركيب الكيميائي

الحجم السعر المخزون الكميّة
1mg
525٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.



Description of Ouabain-d3

Ouabain-d3 is intended for use as an internal standard for the quantification of ouabain by GC- or LC-MS. Ouabain is a cardiac glycoside that has been found in S. gratus and has diverse biological activities.1,2,3,4,5,6,7 It inhibits the Na+/K+-ATPase isoforms α1β1 and α2β1 and human-ether-a-go-go (hERG), also known as Kv11.1 (IC50s = 97, 90, and 15.2 nM, respectively).2,3 Ouabain reduces the proliferation of PC3 prostate cancer and U937 lymphoma cells (EC50s = 210 and 94 nM, respectively).4 It inhibits the cytopathic effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected Vero cells (IC50 = 5 Ouabain (~8 µg/animal) increases systolic blood pressure in normotensive rats.6 It has been used to induce ventricular arrythmias in vivo.7 Formulations containing ouabain have been used in the treatment of atrial fibrillation, atrial flutter, and heart failure.

Chemical Properties of Ouabain-d3

Cas No. SDF
المرادفات g-Strophanthin-d3
Formula C29H41D3O12 M.Wt 587.7
الذوبان Methanol: Slightly soluble,Water: Slightly soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Ouabain-d3

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.7015 mL 8.5077 mL 17.0155 mL
5 mM 340.3 μL 1.7015 mL 3.4031 mL
10 mM 170.2 μL 850.8 μL 1.7015 mL
  • حاسبة المولارية

  • حاسبة التخفيف

  • Molecular Weight Calculator

كتلة
=
تركيز
x
مقدار
x
ميغاواط *
 
 
 
** عند إعداد حلول المخزون، دائمًا استخدم الوزن الجزيئي الخاص بالدفعة للمنتج على ملصق القارورة MSDS / CoA (متوفر عبر الإنترنت).

احسب

In vivo Formulation Calculator (Clear solution) of Ouabain-d3

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

View current batch:

مراجعات

Review for Ouabain-d3

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%