p38 MAPK Inhibitor IV (Synonyms: p38 MAP Kinase Inhibitor IV) |
| رقم الكتالوجGC18602 |
p38 MAPK Inhibitor IV هو p38α عالي التحديد ATP تنافسي ؛ مثبط MAPK مع IC50s 0.13 و 0.55 μ ؛ M لـ p38α ؛ و p38β ؛ MAPK ، على التوالي.
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Cas No.: 1638-41-1
Sample solution is provided at 25 µL, 10mM.
p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.
Reference:
[1]. Liu, Y.C., Ko, C.C., Cheng, F.C., et al. Identification of a novel competitive inhibitor of p38α MAPK by a human PBMC screen. Biochim. Biophys. Res. Commun. 352(3), 656-661 (2007).
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