Palmatine |
| رقم الكتالوجGC39127 |
Palmatine هو مثبط إندوليمين 2،3-ديوكسيجيناز 1 (IDO-1) نشط عن طريق الفم ولا رجعة فيه مع IC50s من 3 ميكرومتر و 157 ميكرومتر مقابل HEK 293-hIDO-1 و rhIDO-1 ، على التوالي
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Cas No.: 3486-67-7
Sample solution is provided at 25 µL, 10mM.
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Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1].
[1]. Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46.
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