Palmitoyl coenzyme A lithium |
| رقم الكتالوجGC67659 |
بالميتويل الإنزيم المساعد أ الليثيوم هو ثيوستر أسيل- CoA يمكن نقله إلى مصفوفة الميتوكوندريا عبر نظام مكوك الكارنيتين ويشارك في β ؛ -الأكسدة. يمكن أيضًا استخدام الليثيوم المساعد بالميتويل A كركيزة لتخليق السفينغوزين الحيوي.
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Cas No.: 188174-64-3
Sample solution is provided at 25 µL, 10mM.
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Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis[1][2].
Palmitoyl coenzyme A lithium (100 μM) reversibly inhibits acetyl coenzyme A carboxylase activity from chicken hepatocytes and is competitive with citric acid and has an important role in the regulation of fatty acid synthesis in vivo[1].
Palmitoyl coenzyme A lithium with a high levels in mitochondria reduces the entry of ADP, which leads to an increased inhibition of glutamate dehydrogenase by palmitoyl CoA[2].
[1]. A G Goodridge, et al. Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate. J Biol Chem. 1972 Nov 10;247(21):6946-52.
[2]. L A Fahien, et al. Regulation of glutamate dehydrogenase by palmitoyl-coenzyme A. Arch Biochem Biophys. 1981 Nov;212(1):247-53.
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