PD 166285 dihydrochloride |
| رقم الكتالوجGC50045 |
PD 166285 ثنائي هيدروكلوريد ، ركيزة من P-gp ، هو مثبط WEE1 ومثبط Myt1 ضعيف بقيم IC50 24 و 72 نانومتر ، على التوالي. يعرض PD 166285 ثنائي هيدروكلوريد IC50 لـ 3.433 μ ؛ M لـ Chk1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 212391-63-4
Sample solution is provided at 25 µL, 10mM.
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Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.
Panek et al (1997) In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. J.Pharmacol.Exp.Ther. 283 1433 PMID:9400019 |Wang et al (2001) Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator. Cancer Res. 61 8211 PMID:11719452 |Hashimoto et al (2006) Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. BMC Cancer 6 292 PMID:17177986
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