PF-06454589 |
| رقم الكتالوجGC64566 |
PF-06447475 هو مثبط كيناز LRRK2 قوي للغاية وانتقائي مخترق للدماغ بقيم IC50 تبلغ 3 نانومتر و 11 نانومتر لـ WT LRRK و G2019S LRRK2 ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1527473-30-8
Sample solution is provided at 25 µL, 10mM.
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PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research[1].
[1]. Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32.
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