PKI 166 hydrochloride |
| رقم الكتالوجGC50083 |
هيدروكلوريد PKI 166 هو مثبط EGFR فعال وانتقائي ونشط عن طريق الفم ، مع IC50 من 0.7 نانومتر.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2230253-82-2
Sample solution is provided at 25 µL, 10mM.
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Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bioavailable.
Bruns et al (2000) Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60 2926 PMID:10850439 |Ulu et al (2013) Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats. J.Pharmacol.Exp.Ther. 345 393 PMID:23528611 |Kaspersen et al (2012) Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena. Bioorg.Chem. 44 35 PMID:22832269
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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