PM 226 |
| رقم الكتالوجGC50387 |
PM 226 هو ناهض CB2R للقنب انتقائي (Ki (CB2R) \u003d 13 نانومتر ؛ EC50 (CB2R) \u003d 39 نانومتر ؛ Ki (CB1R)\u003e 40 ميكرومتر ؛) مع خصائص اعصاب في المختبر والحي.
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Cas No.: 1949726-13-9
Sample solution is provided at 25 µL, 10mM.
Potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microglial activation in a multiple sclerosis mouse model. BBB permeable; anti-inflammatory and neuroprotective.
Navarro et al (2016) Targeting cannabinoid CB2 receptors in the central nervous system. Medicinal chemistry approaches with focus on neurodegenerative disorders. Front. Neurosci. 10 406 PMID:27679556 |Morales et al (2016) Chromenopyrazole, a versatile cannabinoid scaffold with in vivo activity in a model of multiple sclerosis. J.Med.Chem. 59 6753 PMID:27309150 |Gómez-Cañas et al (2016) Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile. Pharmacol.Res. 110 205 PMID:27013280
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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