Polymyxin B |
| رقم الكتالوجGC19581 |
Polymyxin B (PMB) is a potent antibiotic that binds to and neutralizes LPS (lipopolysaccharides).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1404-26-8
Sample solution is provided at 25 µL, 10mM.
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Polymyxin B (PMB) is a potent antibiotic that binds to and neutralizes LPS (lipopolysaccharides)[1].
Polymyxin B againsts all K. pneumoniae strains for positive K. pneumoniae carbapenemase (KPC) genes with MIC of 16 to 128 μg/ml[2]. In vitro,10 µ/mL Polymyxin B was able to neutralize the effect of endotoxin, as contaminant in S. mansoni recombinant antigens produced in E. coli, in inducing TNF-alpha and IL-10 production[1]. The MIC50 and MIC90 values of polymyxin B against 217 strains of carbapenem-resistant A. baumannii were 0.5 and 1 mg/l, respectively[3]. The MIC values for polymyxin B against MRSA (Meticillin-resistant Staphylococcus aureus) was in the range of 8-64 μg/mL, while the MIC values for polymyxin B against MRSP (meticillin-resistant Staphylococcus pseudintermedius) was in the range of 0.25-4 μg/mL[4].
In vivo, mice were treated with 72 mg/kg obviously increased the level of γH2AX foci (indicative of double stranded breaks)[5]. In vivo, carvacrol 10 mg/kg plus polymyxin B 2 mg/kg exhibite antimicrobial activity in a mouse model of infection, resulting in increased survival and a significant decrease in bacterial load in the blood[6].
References:
[1] Cardoso LS, et al. Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1.
[2] Elemam A, et al. In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae. J Clin Microbiol. 2010 Oct;48(10):3558-62.
[3] Thamlikitkul V, et al. In vitro activity of polymyxin B against carbapenem-resistant Acinetobacter baumannii. J Med Assoc Thai. 2014 Dec;97(12):1254-8.
[4] Boyen F, et al. In vitro antimicrobial activity of miconazole and polymyxin B against canine meticillin-resistant Staphylococcus aureus and meticillin-resistant Staphylococcus pseudintermedius isolates. Vet Dermatol. 2012 Aug;23(4):381-5, e70.
[5] Yun B, et al. Polymyxin B causes DNA damage in HK-2 cells and mice. Arch Toxicol. 2018 Jul;92(7):2259-2271.
[6] de Souza GH, et al. Synergistic interaction of polymyxin B with carvacrol: antimicrobial strategy against polymyxin-resistant Klebsiella pneumoniae. Future Microbiol. 2024 Feb 8.
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