Poseltinib (Synonyms: HM71224; LY3337641) |
| رقم الكتالوجGC60298 |
Poseltinib ، مثبط التيروزين كيناز (BTK) النشط عن طريق الفم والانتقائي وغير القابل للانعكاس (IC50 = 1.95 نانومتر) ، مع انتقائية 0.3 و 2.3 و 2.4 ضعف لـ BTK على BMX و TEC و TXK ، على التوالي
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Cas No.: 1353552-97-2
Sample solution is provided at 25 µL, 10mM.
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Poseltinib, an orally active, selective and irreversible Bruton's tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling[1].
[1]. Kim YY, et al. HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus. Arthritis Res Ther. 2017 Sep 26;19(1):211.
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