PQ-10 |
| رقم الكتالوجGC44673 |
PQ-10 هو مثبط قوي لـ Phosphodiesterase 10A (PDE10A) مع IC50 و ED50 من 4.6 نانومتر و 13 مجم / كجم على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 927691-21-2
Sample solution is provided at 25 µL, 10mM.
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PQ-10 is a potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM). It has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro. Subcutaneous injection of PQ-10 (32 mg/kg) leads to increases in striatal cGMP and phosphorylation of cAMP response element binding protein (CREB) in murine striatum, known markers of in vivo PDE10 inhibition. PQ-10 at a dose of 0.3 mg/kg, p.o., reduces scopolamine- and MK-801-induced memory deficits in rats. PQ-10 also inhibits tumor cell growth with IC50 values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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