Propargyl-PEG4-thiol |
| رقم الكتالوجGC67451 |
Propargyl-PEG4-thiol هو رابط PROTAC قائم على PEG يمكن استخدامه في تخليق PROTACs. Propargyl-PEG4-thiol هو رابط ADC غير قابل للكسر يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs).
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Cas No.: 1347750-80-4
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG4-thiol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Goswami LN, et al. Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery.
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