(R)-BMS-816336 |
| رقم الكتالوجGC39029 |
(R) -BMS-816336 (المركب 6n-1) هو مثبط فعال وفعال عن طريق الفم للإنسان والفأر والقرد cynomolgus 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) مع IC50s من 14.5 نانومتر ، 50.3 نانومتر و 16 نانومتر ، على التوالي
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Cas No.: 1009583-83-8
Sample solution is provided at 25 µL, 10mM.
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(R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 14.5 nM, 50.3 nM and 16 nM, respectively [1].
[1]. Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948.
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