Ranirestat (AS-3201) |
| رقم الكتالوجGC31359 |
Ranirestat (AS-3201) (AS-3201) مثبط اختزال الألدوز (AR) الفعال والفعال عن طريق الفم مع IC50s من 11 نانومتر و 15 نانومتر لعدسة الفئران AR و AR المؤتلف البشري ، على التوالي ، و Ki 0.38 نانومتر لـ AR المؤتلف البشري .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 147254-64-6
Sample solution is provided at 25 µL, 10mM.
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Ranirestat (AS-3201) is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.
[1]. Kurono M, et al. Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: a significant role of specific binding by serum albumin in the improved potency and stability. Biochem Pharmacol. 2006 Jan 12;7 [2]. Matsumoto T, et al. Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. J Pharmacol Sci. 2009 Feb;109(2):203-10. [3]. Toyoda F, et al. Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res. 2014;2014:672590.
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