RBN-2397 |
| رقم الكتالوجGC39504 |
يعتبر RBN-2397 من الأنواع القوية والمتقاطعة والمثبط التنافسي NAD + التنافسي لـ PARP7 (IC50 <3 نانومتر)يرتبط RBN-2397 بشكل انتقائي بـ PARP7 (Kd =0.001 ميكرومتر) ويستعيد إشارات IFNيمتلك RBN-2397 القدرة على دراسة الأورام الصلبة المتقدمة أو النقيلية
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2381037-82-5
Sample solution is provided at 25 µL, 10mM.
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RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores interferon (Type I) signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors[1][2].
[1]. RBN-2397-Inhibiting PARP7, a Key monoPARP Cancer Dependency [2]. Melissa Vasbinder, et al. RBN-2397: A First-in-Class PARP7 Inhibitor Targetinga Newly Discovered Cancer Vulnerability in Stress-Signaling Pathways.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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