RET-IN-3 |
| رقم الكتالوجGC61243 |
RET-IN-3 (المركب 34) هو مثبط انتقائي لـ RETV804M كيناز ، مع IC 50 من 19 نانومتر
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Cas No.: 2414374-53-9
Sample solution is provided at 25 µL, 10mM.
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RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].
RET-IN-3 exhibits 16 and 410 fold selectivity compared to wt-RET and KDR, respectively[1].
[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.
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