Rintodestrant (Synonyms: G1T48) |
| رقم الكتالوجGC63464 |
Rintodestrant (G1T48) هو مادة فعالة عن طريق الفم ، وغير ستيرويدية وانتقائية لمستقبلات هرمون الاستروجينRintodestrant (G1T48) هو أيضًا مثبط CDK4 / 6
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Cas No.: 2088518-51-6
Sample solution is provided at 25 µL, 10mM.
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Rintodestrant (G1T48) is an orally active, non-steroidal and selective estrogen receptor degrader. Rintodestrant (G1T48) is also a CDK4/6 inhibitor[1].
Rintodestrant (G1T48) is a potent and efficacious inhibitor of estrogen-mediated transcription and proliferation in ER-positive breast cancer cells, similar to the pure antiestrogen fulvestrant[1].Rintodestrant (G1T48) selectively inhibits the growth of ER-positive, but not ER-negative, breast cancer cells[1].
Rintodestrant (G1T48, 30 or 100 mg/kg) inhibits estrogen signaling in endocrine-resistant breast cancer models[1].
[1]. Kaitlyn J Andreano, et al. G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. Breast Cancer Res Treat. 2020 Apr;180(3):635-646.
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