(S)-(+)-Ibuprofen (Synonyms: Dexibuprofen, (+)-Ibuprofen) |
| رقم الكتالوجGC13114 |
(S) - (+) - ايبوبروفين ((S) - ايبوبروفين) ، S (+) - متماثل ايبوبروفين ، هو مثبط قوي لـ COX-1 و COX-2 مع IC50s من 2.1 ميكرومتر و 1.6 ميكرومتر ، على التوالي
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Cas No.: 51146-56-6
Sample solution is provided at 25 µL, 10mM.
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(S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].
References:
[1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.
[2]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52.
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