الصفحة الرئيسية>>Signaling Pathways>> Others>> Transcription Factors>>(S)-(+)-Methoprene

(S)-(+)-Methoprene (Synonyms: Altosid, d-Methoprene, ZR 2458)

رقم الكتالوجGC46347

(S) - الميثوبرين هو نظير هرمون الأحداث الذي يحظر قدرة الحشرة على التحول من الشرانق إلى الكبار ويستخدم كمبيد حشري.

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(S)-(+)-Methoprene التركيب الكيميائي

Cas No.: 65733-16-6

الحجم السعر المخزون الكميّة
100mg
35٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (S)-(+)-Methoprene

(S)-(+)-Methoprene is a widely-used insect growth regulator.1 It is remarkable for its lack of significant effects against a wide variety of mammals, although concerns remain for its effects on arthropod development.1,2 Methoprene acts as an activator of the juvenile hormone receptor, known as Methoprene-tolerant or Met (Kd = 12.3 nM).3,4 Met is a transcription factor that, upon activation with juvenile hormone or methoprene, regulates gene expression that inhibits metamorphosis.5

1.Siddall, J.B.Insect growth regulators and insect control: A critical appraisalEnvironmental Health Perspectives14119-126(1976) 2.Wright, J.E.Environmental and toxicological aspects of insect growth regulatorsEnvironmental Health Perspectives14127-132(1976) 3.Charles, J.P., Iwema, T., Epa, V.C., et al.Ligand-binding properties of a juvenile hormone receptor, methoprene-tolerantProceedings of the National Academy of Sciences of the United States of America108(52)21128-21133(2011) 4.Osir, E.O., and Riddiford, L.M.Nuclear binding sites for juvenile hormone and its analogs in the epidermis of the tobacco hornwormThe Journal of Biological Chemisty263(27)13812-13818(1988) 5.Zou, Z., Saha, T.T., Roy, S., et al.Juvenile hormone and its receptor, methoprene-tolerant, control the dynamics of mosquito gene expressionProceedings of the National Academy of Sciences of the United States of America110(24)E2173-E2181(2013)

Chemical Properties of (S)-(+)-Methoprene

Cas No. 65733-16-6 SDF
المرادفات Altosid, d-Methoprene, ZR 2458
Canonical SMILES CC(C)OC(/C=C(C)/C=C/C[C@@H](C)CCCC(OC)(C)C)=O
Formula C19H34O3 M.Wt 310.5
الذوبان DMF: 20 mg/ml,Ethanol: 10 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (S)-(+)-Methoprene

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.2206 mL 16.1031 mL 32.2061 mL
5 mM 0.6441 mL 3.2206 mL 6.4412 mL
10 mM 0.3221 mL 1.6103 mL 3.2206 mL
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In vivo Formulation Calculator (Clear solution) of (S)-(+)-Methoprene

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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