SMAP-2 (Synonyms: DT-1154) |
| رقم الكتالوجGC39440 |
SMAP-2 (DT-1154) هو منشط بروتين فوسفاتيز 2A (PP2A) نشط عن طريق الفم ، مع نشاط مضاد للسرطان
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Cas No.: 1809068-70-9
Sample solution is provided at 25 µL, 10mM.
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SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].
[1]. Sangodkar J, et al. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017 Jun 1;127(6):2081-2090.
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