T 26c disodium salt |
| رقم الكتالوجGC50353 |
Highly potent and selective MMP13 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 869298-22-6
Sample solution is provided at 25 µL, 10mM.
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Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable.
Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1" binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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