Tetrahydroxystilbene-2-O-β-D-glucoside (Synonyms: tetrahydroxyl diphenylethylene-2-o-gluco, EH-201) |
| رقم الكتالوجGC26316 |
Tetrahydroxysilbene-2-O- β- D-glucoside (EH-201) is a low molecular weight erythropoietin inducer.
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Cas No.: 55327-45-2
Sample solution is provided at 25 µL, 10mM.
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Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astrocytes and PC12 neuronal-like cells. In vivo, Tetrahydroxystilbene-2-O-β-D-glucoside treatment restores memory impairment, as assessed by the passive avoidance test, in SD, Aβ and KA mouse models. In the hippocampus of mice given Tetrahydroxystilbene-2-O-β-D-glucoside in their diet, levels of erythropoietin, PGC-1α and haemoglobin were increased. Treatment with Tetrahydroxystilbene-2-O-β-D-glucoside might be a therapeutic strategy for memory impairment in neurodegenerative disease, physiological ageing or traumatic brain injury.
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