Trimethobenzamide hydrochloride (Ro 2-9578) (Synonyms: Ro 2-9578) |
| رقم الكتالوجGC33527 |
هيدروكلوريد ثلاثي ميثوبنزاميد (Ro 2-9578) هو مانع لمستقبل D2.
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Cas No.: 554-92-7
Sample solution is provided at 25 µL, 10mM.
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Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.
Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1].
The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1].
[1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42.
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