VU0134992 hydrochloride |
| رقم الكتالوجGC39667 |
هيدروكلوريد VU0134992 هو أول نوع فرعي مفضل ، فعال عن طريق الفم وانتقائي من نوع Kir4.1 مانع مسام قناة البوتاسيوم ، مع IC 50 من 0.97 ميكرومتر
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Cas No.: 1052515-91-9
Sample solution is provided at 25 µL, 10mM.
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VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV[1].
[1]. Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937.
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